Registration Dossier
Registration Dossier
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EC number: 217-830-6 | CAS number: 1975-78-6
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Link to relevant study records
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- There is no data available on the genetic toxicity of Caprinonitrile (Decannitrile). In order to classify the substance according to GHS relevant endpoint data available for Dodecannitrile was read-acrossed to Caprinonitrile based on structural similarities. Dodecannitrile is as well as Decanntrile based on aliphatic chains of hydrocarbon atoms. These chains which consist of an even-numbered number of hydrocarbon atoms, are saturated and possess a nitrile-group at its end. Decannitrile consists of 10 hydrocarbon atoms and Dodecannitrile is the next higher analogon with 12 hydrocarbon atoms. Generally it can be assumed that the next lower analogon (Decannitrile) has the same properties as the basic substance (Dodecannitrile). Furthermore it is obvious that if any chemical reaction takes place with those two substances then the nitrile group is the only functional group of this chemicals were a reaction should occur.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 472 (Genetic Toxicology: Escherichia coli, Reverse Mutation Assay)
- GLP compliance:
- not specified
- Type of assay:
- other: AMES test
- Conclusions:
- Interpretation of results (migrated information):
negative with metabolic activation
negative without metabolic activation - Executive summary:
There is no data available on Genetic Toxicity tests with Caprinonitrile (Decannitrile). In order to classify the substance according to GHS relevant endpoint data available for Dodecannitrile is read-acrossed to Caprinonitrile based on structural similarities (see rationale for reliablilty).
Available data for Dodecannitrile was found in an IUCLID 4 dataset of the substance Cocosnitrile (CAS: 61789 -53 -5, EC: 263 -066 -1). In this dataset results of several AMES Tests (according to OECD 471 or OECD 472 under GLP) are given:
1) OECD 471 (S. thyphimurium): negative with and without metabolic activation
2) OECD 471 (S. thyphimurium): negative with and without metabolic activation
3) OECD 472 (E. coli): negative with and without metabolic activation
4) OECD 472 (E. coli): negative with and without metabolic activation
In order to classify the substance Caprinonitrile (without any unnecessary animal testing) this results for Dodecannitrile are read acrossed and lead to a non-classification of Caprinonitrile in genetic toxicity (according to GHS).
Reference
- no further details available
- inforamtion only used for classification
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Additional information
Justification for classification or non-classification
There is no data available on Genetic Toxicity tests with Caprinonitrile (Decannitrile). In order to classify the substance according to GHS relevant endpoint data available for Dodecannitrile is read-acrossed to Caprinonitrile based on structural similarities (see rationale for reliablilty).
Available data for Dodecannitrile was found in an IUCLID 4 dataset of the substance Cocosnitrile (CAS: 61789 -53 -5, EC: 263 -066 -1). In this dataset results of several AMES Tests (according to OECD 471 or OECD 472 under GLP) are given:
1) OECD 471 (S. thyphimurium): negative with and without metabolic activation
2) OECD 471 (S. thyphimurium): negative with and without metabolic activation
3) OECD 472 (E. coli): negative with and without metabolic activation
4) OECD 472 (E. coli): negative with and without metabolic activation
In order to classify the substance Caprinonitrile (without any unnecessary animal testing) this results for Dodecannitrile are read acrossed and lead to a non-classification of Caprinonitrile in genetic toxicity (according to GHS).
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