Decanenitrile

Endpoint summary

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Reference

Endpoint:

acute toxicity: oral

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

There is no data available on the oral toxicity of Caprinonitrile (Decannitrile). In order to classify the substance according to GHS relevant endpoint data available for Dodecannitrile was read-acrossed to Caprinonitrile based on structural similarities. Dodecannitrile is as well as Decanntrile based on aliphatic chains of hydrocarbon atoms. These chains which consist of an even-numbered number of hydrocarbon atoms, are saturated and possess a nitrile-group at its end. Decannitrile consists of 10 hydrocarbon atoms and Dodecannitrile is the next higher analogon with 12 hydrocarbon atoms. Generally it can be assumed that the next lower analogon (Decannitrile) has the same properties as the basic substance (Dodecannitrile). Furthermore it is obvious that if any chemical reaction takes place with those two substances then the nitrile group is the only functional group of this chemicals were a reaction should occur.

Qualifier:

according to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

not specified

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Dose descriptor:

LD50

Effect level:

ca. 3 400 mg/kg bw

Interpretation of results:

not classified

Remarks:

Migrated information

Executive summary:

There is no data available for the oral toxicity of Caprinonitrile (Decannitrile). In order to classify the substance according to GHS relevant endpoint data available for Dodecannitrile is read-acrossed to Caprinonitrile based on structural similarities (see rationale for reliablilty).

Available data for Dodecannitrile was found in an IUCLID 4 dataset of the substance Cocosnitrile (CAS: 61789 -53 -5, EC: 263 -066 -1). In this dataset several LD50 values of Acute Oral Toxicity Studies (according to OECD 401 under GLP) are given:

1) LD50 (oral) >2000mg/kg bw

2) LD50 (oral) = approx. 3400 mg/kg bw

In order to classify the substance Caprinonitrile (without any unnecessary animal testing) this results for Dodecannitrile are read acrossed and lead to a non-classification of Caprinonitrile in acute oral toxicity (according to GHS).

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed

Dose descriptor:

LD50

Value:

2 000

Justification for classification or non-classification

Caprinonitrile is not classified as acute toxic (oral). Because there was not any studies available for this endpoint with Caprinonitrile, three studies with the substances Dodecannitrile and Cocosnitrile were read-accrossed in order to classify the substance according to GHS. The read across is based on structural similarities. Dodecannitrile and Cocosnitrile as well as Decanntrile are based on aliphatic chains of hydrocarbon atoms. These chains which consist of an even-numbered number of hydrocarbon atoms, are saturated and possess a nitrile-group at its end. Decannitrile consists of 10 hydrocarbon atoms and Dodecannitrile is the next higher analogon with 12 hydrocarbon atoms. Although Cocosnitrile is not a pure substance it only consists of the even-numbered anologons C8 – C18 of Caprinonitrile. Furthermore it is obvious that if any chemical reaction takes place with those three substances then the nitrile group is the only functional group of this chemicals were a reaction should occur (without any further activation).

All three test showed a result of LD50 > 2000 mg/kg bw. Because of this the substance Caprinonitrile was also classified as non acute toxic (oral).