Decanenitrile

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

There is no data available on skin irritation tests with Caprinonitrile (Decannitrile). In order to classify the substance according to GHS relevant endpoint data available for Dodecannitrile was read-acrossed to Caprinonitrile based on structural similarities. Dodecannitrile is as well as Decanntrile based on aliphatic chains of hydrocarbon atoms. These chains which consist of an even-numbered number of hydrocarbon atoms, are saturated and possess a nitrile-group at its end. Decannitrile consists of 10 hydrocarbon atoms and Dodecannitrile is the next higher analogon with 12 hydrocarbon atoms. Generally it can be assumed that the next lower analogon (Decannitrile) has the same properties as the basic substance (Dodecannitrile). Furthermore it is obvious that if any chemical reaction takes place with those two substances then the nitrile group is the only functional group of this chemicals were a reaction should occur.

Data source

Reference

Reference Type:

other: IUCLID 4 dataset

Title:

IUCLID 4 dataset, Cocosnitrile

Bibliographic source:

European Comission - European Chemicals Bureau

Report date:

2000

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 404 (Acute Dermal Irritation / Corrosion)

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Dodecanenitrile

EC Number:

219-440-1

EC Name:

Dodecanenitrile

Cas Number:

2437-25-4

Molecular formula:

C12H23N

IUPAC Name:

dodecanenitrile

Results and discussion

Any other information on results incl. tables

- no further details available

- information only used for classification

Applicant's summary and conclusion

Interpretation of results:

Category 2 (irritant)

Remarks:

Migrated information

Executive summary:

There is no data available on the skin irritation of Caprinonitrile (Decannitrile). In order to classify the substance according to GHS relevant endpoint data available for Dodecannitrile is read-acrossed to Caprinonitrile based on structural similarities (see rationale for reliablilty).

Available data for Dodecannitrile was found in a IUCLID 4 dataset of the substance Cocosnitrile (CAS: 61789 -53 -5, EC: 263 -066 -1). In this dataset two studies on skin irritation with Dodecannitrile (according to OECD 404 under GLP) are metioned. Both disclose irritation after a four hour lasting application with Dodecannitrile.

In order to classify the substance Caprinonitrile (without any unnecessary animal testing) this results for Dodecannitrile are read acrossed and lead to a classification of Caprinonitrile as Skin irritating Cat. 2 (according to GHS).