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EC number: 265-745-8
CAS number: 65405-77-8
Table 1: Mortality
Dose group (mg/kg)
Dead animals after 1 h
Table 2: Body Weights
start of testing
Table 3: Clinical Signs
30 min - 3 h (10)
30 min (1)
1 - 3 h (10)
1 d (1)
In prone position
Increased respiratory frequency
1 d (7)
2 d (4)
2 d (1)
1-3 h (1)
3.5-6.5 h (1)
1-3 h (10)
1 d (2)
2 d (5)
2 d (2)
The acute oral toxicity of the test material was determined under GLP
conditions to the standardised guideline OECD 401. During the study 10
male and 10 female rats were dosed orally, by gavage, with a single
administration of test material in arachidic oil. Animals were dosed at
2000, 2510, 3160 and 3980 mg/kg and were observed for a period of 14
days post administration for mortality and clinical signs; body weights
were also recorded. Fourteen days following test material administration
animals were sacrificed and an assessment of the internal organs was
performed. Under the conditions of the study seven 3980 mg/kg males died
one day following dose administration, a further male died on day 2. Two
days following dose administration four 3160 mg/kg males and one 2510
mg/kg male died. All of the male animals dosed at 2000 mg/kg survived
until the end of the study. Two days following dose administration nine
3980 mg/kg females, five 3160 mg/kg females and two 2510 females mg/kg
died. One 2000 mg/kg female died seven days after dose administration.
All remaining animals survived until the end of the study. The LD50 of
the test material was subsequently determined to be 3339 mg/kg in males
and 3031 mg/kg in females.
The test material is considered sufficiently similar to (z)-3-hexenyl
salicylate on the basis of read-across such that the results from this
study can be used to address the acute oral toxicity of (z)-3-hexenyl
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