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EC number: 265-745-8
CAS number: 65405-77-8
NOAEL(oral) converted to NOAEC(inhal) (180 mg/kg x [1/0.38 x 50% oral
absorption rat/100% inhalation absorption human x 6.7/10]) = 159 mg/m3
NOAEL(oral) converted to NOAEL(dermal) (180 mg/kg x [50% oral absorption
rat/25% dermal absorption humans]) = 360 mg/kg bw/day
(z)-3-hexenyl salicylate does not show any local or acute effects and so
DNELs for local and/or acute effects have not been calculated.
The available one generation reproduction study is considered as the
most relevant study for the dose descriptor starting point and the NOAEL
of 180 mg/kg bw/day (general parental toxicology, parental female
reproduction and F1 generation development) from this study has been
used as the starting point for the calculation of the systemic DNELs.
DNELs calculated using OECD 422 study results give a higher DNEL than
those based on one generation reproduction study - therefore at present
it is considered a worst case assessment to use the current DNELs.
DNELs will be re-evaluated based on 90 -day repeat dose toxicity (OECD
408) and pre-natal development toxicity (OECD 414) study results
(conducted on substance itself) once available.
NOAEL(oral) converted to NOAEC(inhal) (180 mg/kg x [1/1.15 x 50% oral
absorption rat/100% inhalation absorption human]) = 78.2 mg/m3
Same oral absorption in rat and humans
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