Registration Dossier
Registration Dossier
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EC number: 207-330-6 | CAS number: 462-95-3
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: not glp, no material and methods described. Just results and remarks indicated
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Internal SOP TA 330 and TA 150
- GLP compliance:
- no
Test material
- Reference substance name:
- Diethoxymethane
- EC Number:
- 207-330-6
- EC Name:
- Diethoxymethane
- Cas Number:
- 462-95-3
- Molecular formula:
- C5H12O2
- IUPAC Name:
- diethoxymethane
- Details on test material:
- - Name of test material (as cited in study report): Diethoxymethane
- Accession No: 900748
- HAEL No: 86-0012
- Source reference ID No: X-19085-9
- Source: Tennessee Eastman Company
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- 0.1 ml
- Duration of treatment / exposure:
- immediate
- Observation period (in vivo):
- 14 days
- Number of animals or in vitro replicates:
- 6 (3/3)
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): 3 washed (distilled water), 3 unwashed
- Time after start of exposure: immediately after
SCORING SYSTEM:
TOOL USED TO ASSESS SCORE: fluorescein
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Reversibility:
- fully reversible within: 72 h
- Remarks on result:
- other: test article is a slight eye irritant
Applicant's summary and conclusion
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- The test article was a slight eye irritant. It caused slight erythema of the adnexa and staining of the nictitating membrane with fluorescein dye. Immediate washing did not noticeably alter the irritant reaction. All washed and unwashed eyes appeared clinically normal by 72 hours after administration of the test material.
- Executive summary:
The test article was a slight eye irritant. It caused slight erythema of the adnexa and staining of the nictitating membrane with fluorescein dye. Immediate washing did not noticeably alter the irritant reaction. All washed and unwashed eyes appeared clinically normal by 72 hours after administration of the test material.
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