Registration Dossier
Registration Dossier
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EC number: 207-330-6 | CAS number: 462-95-3
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1986-1987
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: not GLP, no material and methods described. Just the results and remarks
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: internal SOP TA 320 and TA 160
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Diethoxymethane
- EC Number:
- 207-330-6
- EC Name:
- Diethoxymethane
- Cas Number:
- 462-95-3
- Molecular formula:
- C5H12O2
- IUPAC Name:
- diethoxymethane
- Details on test material:
- - Name of test material (as cited in study report): Diethoxymethane
- Accession No: 900748
- HAEL No: 86-0012
- Source reference ID No: X-19085-9
- Source: Tennessee Eastman Company
Constituent 1
Test animals
- Species:
- guinea pig
- Strain:
- other: CRL: (HA)BR Hartley
- Details on test animals or test system and environmental conditions:
- Initial body weight range: 436-454 g
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5 ml
- Duration of treatment / exposure:
- 24h
- Observation period:
- 2 weeks
- Number of animals:
- 5
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24/48 h
- Reversibility:
- fully reversible
- Remarks on result:
- other: Abnormalities noted at the site of application were restricted to very slight Edema
Applicant's summary and conclusion
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- The test material was, at most, a slight skin irritant. Abnormalities noted at the site of application following exposure of depilated abdomens of guinea pigs to 0.5 ml of the test material under an occlusive wrap for 24 hours were restricted to very slight edema
- Executive summary:
The test material was, at most, a slight skin irritant. Abnormalities noted at the site of application following exposure of depilated abdomens of guinea pigs to 0.5 ml of the test material under an occlusive wrap for 24 hours were restricted to very slight edema
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