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EC number: 236-152-1 | CAS number: 13194-48-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1986-04-21 to 1986-06-11
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Ethoprophos
- EC Number:
- 236-152-1
- EC Name:
- Ethoprophos
- Cas Number:
- 13194-48-4
- Molecular formula:
- C8H19O2PS2
- IUPAC Name:
- ethyl bis(propylsulfanyl)phosphinate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Rationale for alternative/additional species to rat:
The rabbit is the system of choice since it has been used historically for this type of study and will allow the data to be compared to those for other compounds.
- Source: Gota-Frisco Farms
- Age at study initiation: not specified
- Weight at study initiation: 1.7 to 2.7 kg
- Housing: individually housed in suspended stainless steel wire mesh bottom cages
- Diet (ad libitum): Agway Prolab Rabbit Ration
- Water (ad libitum): yes
- Acclimation period: at least 7 days
- Method of randomisation in assigning animals to test and control groups:
ENVIRONMENTAL CONDITIONS
- Temperature (°C): approx. 22
- Humidity (%): 30 - 70
- Air changes (per hr): not specified
- Photoperiod (hrs dark / hrs light): 12/12
IN LIFE DATES: From: 1986-05-20 To: 1986-06-11
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 8 x 10 cm (0.1 µL/mmE2)
- Type of wrap: a porous 8 ply gauze patch measuring 2 x 2 cm was secured over the treated skin and a stockinette sleeve placed around the animals trunk (non-irritating tape was used to secure both)
REMOVAL OF TEST SUBSTANCE
- Washing: test site was gently wiped with water soaked gauze
- Time after start of exposure: 24 h
TEST MATERIAL
- Amount applied:
The dose volume was calculated for each animal according to the following formula, considering a density of 1090 mg/mL:
Dose Volume (mL) = (dosage level (mg/kg)) / (test item density) * body weight (kg)
- Constant volume used: no - Duration of exposure:
- 24 h
- Doses:
- - 3.6 mg/kg bw (test site: 70 mmE2)
- 6.0 mg/kg bw (test site: 120 mmE2)
- 16.7 mg/kg bw (test site: 300 mmE2) - No. of animals per sex per dose:
- 10 animals per sex and dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 15 days
- Frequency of observations and weighing: three times on day of administration and once daily thereafter, mortality checks were performed twice daily (5 h apart).
Individual body weight was measured on days 1, 8 and 15, or at death.
- Necropsy of survivors performed: yes
- Clinical signs:
In addition to examination forb pharmacotoxic signs, particular attention was directed during clinical observations for tremors, convulsions, lethargy or other potential central nervous system effects. - Statistics:
- The LD50 for each sex and for both sexes combined was computed by the method of Probit Analysis.
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 8.5 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 9.3 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 7.9 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Deaths occurred at 6.0 (3M, 1F), 10.0 (8M, 8F) and 16.7 mg/kg bw (9M, 8F).
- Clinical signs:
- other: other: see "Remark"
- Body weight:
- other body weight observations
- Gross pathology:
- Gross necropsy revealed discoloured gastrointestinal tract contents and red discolouration of the respiratory tract in decedents; no treatment-related findings were noted in survivors.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 based on GHS criteria
- Conclusions:
- The acute dermal LD50 of the test item in the rabbit was calculated to be 7.9 mg/kg bw (males), 9.3 mg/kg bw (females) and 8.5 mg/kg bw (combined) under the conditions of this study.
- Executive summary:
In a 1987 study similar to OECD 402, the test substance was applied for 24 hours under semi-occlusive conditions to the shorn dorsal skin of New Zealand White rabbits (10/sex/group) at dose levels of 3.6, 6.0, 10.0 or 16.7 mg/kg bw. Animals were observed for 14 days.
Deaths occurred at 6.0 (3M, 1F), 10.0 (8M, 8F) and 16.7 mg/kg bw (9M, 8F). Signs of toxicity were noted at 3.6 (loss of locomotor ability, ataxia, soft stools), 6.0 (additionally salivation, prostration, laboured breathing and diarrhoea), 10.0 and 16.7 mg/kg bw (additionally red fluid around the mouth). Transient weight loss was seen in a number of animals at all dose levels, however with the exception of one top dose male, all surviving animals gained weight over the study period. Gross necropsy revealed discoloured gastrointestinal tract contents and red discolouration of the respiratory tract in decedents; no treatment-related findings were noted in survivors.The acute dermal LD50 of the test item in the rabbit was calculated to be 7.9 mg/kg bw (males), 9.3 mg/kg bw (females) and 8.5 mg/kg bw (combined) under the conditions of this study.
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