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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

Currently viewing:

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
presumably 1975
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Methodical details are missing

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1975

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
3 male albino rabbits were used. The abdomen was closely clipped and 1 mL/kg bw was placed on the intact skin daily for 4 days. The animals were observed daily and for a period of 36 h after the last application.
GLP compliance:
not specified
Test type:
other: Data from a dermal skin irritation study are used, as 1 mL/kg bw (ca. 1000 mg/kg) was administered to rabbits
Limit test:
no

Test material

Constituent 1
Test material form:
not specified
Details on test material:
no data

Test animals

Species:
rabbit
Strain:
other: Albino
Sex:
male
Details on test animals or test system and environmental conditions:
no data

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Details on dermal exposure:
TEST SITE
abdomen (intact skin)
Duration of exposure:
daily for 4 days
Doses:
1 mL/kg bw (ca. 1000 mg)
No. of animals per sex per dose:
3 m
Control animals:
no
Details on study design:
The abdomen was closely clipped and 1 mL/kg bw was placed on the intact skin daily for 4 days. The animals were observed daily and for a period of 36 h after the last application.
Statistics:
no data

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
approximate LD50
Effect level:
> 1 000 mg/kg bw
Mortality:
No evidence
Clinical signs:
other: No evidence
Gross pathology:
no data

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information
Conclusions:
ATBC did not induce toxic signs when applied to 3 rabbits over 4 consecutive days.
Executive summary:

In a skin irritation study, which likewise could be used as acute dermal toxicity study (ATBC was applied to rabbits over 4 days at a dosage of 1 mL/kg bw/d; ca. 1000 mg/kg), no signs of toxicity were noted. Therefore it can be concluded that ATBC is not toxic after dermal administration to rabbits at a daily dermal dose of ca. 1000 mg/kg.