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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1959
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Older study: meets scientific standards with acceptable restrictions (limited number of animals in study, partly limited documentation)

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Unnamed
Year:
1959
Reference Type:
study report
Title:
Unnamed
Year:
1959

Materials and methods

Test guideline
Qualifier:
no guideline available
Guideline:
other: Study from 1959 (no guidelines available at the time the study was performed)
Deviations:
not applicable
GLP compliance:
no
Remarks:
Study from 1959 (GLP was not compulsory at the time the study was performed)
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Test material form:
not specified
Details on test material:
Name of test material (as cited in study report): Acetyl tributyl citrate (CAS RN 77-90-7)
Analytical purity: not stated

Test animals

Species:
rat
Strain:
Wistar
Sex:
not specified

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Doses:
Single dosing with 10 - 30 mL/kg (ca. 10.5 - 31.5 g)
No. of animals per sex per dose:
Dosed was a group of 5 animals (no further details reported)
Control animals:
not specified
Details on study design:
Duration of observation period following administration: 21 d
Frequency of observations and weighing: not reported
Necropsy of survivors performed: not reported
Other examinations performed: body weight,organ weights, histopathology
Statistics:
Not further specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 31 500 mg/kg bw
Remarks on result:
other: Endpoint was estimated, as there were no signs of toxicity to be found at test doses
Mortality:
No deaths occured at any dose level throughout the study.
Clinical signs:
other: Shortly after administration, the material began to leak from the rectum. Transient sluggishness was reported.
Gross pathology:
Not reported

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category V
Remarks:
Migrated information
Conclusions:
In this older study with Wistar rats the LD50 was estimated with > 30 mL/kg (ca. 31500 mg/kg)
Executive summary:
In this older study Wistar rats were dosed once with 10 - 30 mL/kg (ca. 10500 - 31500 mg/kg) via gavage. All animals were observed for signs of toxicity for 21 d following dosing. The dosing caused no deaths and the estimated LD50 was given with > 30 mL/kg (ca. 31500 mg/kg).