Tributyl O-acetylcitrate

Eye irritation

Administrative data

Endpoint:

eye irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Study period:

presumably 1975

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Methodical details are missing

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1975

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

3 male albino rabbits were used. 0.1 mL was instilled once into the left conjunctival sac, while the right eyes were used as controls. Observations were made at 20 min and at 3 – 72 h after application.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Test material form:

not specified

Details on test material:

no data

Test animals / tissue source

Species:

rabbit

Strain:

other: Albino

Details on test animals or tissues and environmental conditions:

no data

Test system

Vehicle:

not specified

Controls:

other: right eyes were used as controls

Amount / concentration applied:

0.1 mL

Duration of treatment / exposure:

single application

Observation period (in vivo):

Observations were made at 20 min and at 3 – 72 h after application.

Number of animals or in vitro replicates:

3 m

Details on study design:

SCORING SYSTEM: no data

Results and discussion

In vivo

Results

Irritation parameter:

overall irritation score

Remarks on result:

other: slight irritation was observed

Any other information on results incl. tables

Within 20 min moderate erythema in 2/3 rabbits, which persisted at the 3 h observation period and subsided in 1 of the 2 two rabbits after 5 hours. At 24 h moderate erythema in one rabbit was slightly increased, while the other two rabbits were negative. At 48 and 72 h all the eyes were essentially negative.

Applicant's summary and conclusion

Interpretation of results:

slightly irritating

Remarks:

Migrated information

Conclusions:

ATBC was slightly eye irritating

Executive summary:

3 male albino rabbits were used. 0.1 mL was instilled once into the left conjunctival sac, while the right eyes were used as controls. Observations were made at 20 min and at 3 – 72 h after application.

Within 20 min moderate erythema in 2/3 rabbits, which persisted at the 3 h observation period and subsided in 1 of the 2 two rabbits after 5 hours. At 24 h moderate erythema in one rabbit was slightly increased, while the other two rabbits were negative. At 48 and 72 h all the eyes were essentially negative.