Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 222-182-2 | CAS number: 3380-34-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Health surveillance data
Administrative data
- Endpoint:
- health surveillance data
- Type of information:
- other: not applicable
- Adequacy of study:
- weight of evidence
- Reliability:
- other: not applicable since statement
- Rationale for reliability incl. deficiencies:
- other: not applicable since statement
Data source
Reference
- Reference Type:
- other: Statement
- Title:
- Unnamed
- Year:
- 2 006
Materials and methods
- Study type:
- health record from industry
- Endpoint addressed:
- not applicable
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- no
- Remarks:
- not applicable
Test material
- Reference substance name:
- Triclosan
- EC Number:
- 222-182-2
- EC Name:
- Triclosan
- Cas Number:
- 3380-34-5
- Molecular formula:
- C12H7Cl3O2
- IUPAC Name:
- 5-chloro-2-(2,4-dichlorophenoxy)phenol
- Details on test material:
- Irgasan DP 300 Triclosan
Constituent 1
Method
- Type of population:
- occupational
- Details on study design:
- Employees of Triclosan production of Ciba Specialty Chemicals- production site Grenzach - regularly receive medical check-ups according to national requirements (Gefahrstoffverordnung, Biostoffverordnung), to local regulations of accident insurance (Berufsgenossenschaft der chemischen Industrie) as well as to Environment, Health and Safety Policy of Ciba Specialty Chemicals.
Results and discussion
- Results:
- Employees of triclosan production of Ciba Specialty Chemicals - production site Grenzach - regularly receive medical check-ups according to national requirements (Gefahrstoffverordnung, Biostoffverordnung), to local regulations of accident insurance (Berufsgenossenschaft der chemischen Industrie) as well as to Environment, Health and Safety Policy of Ciba Specialty Chemicals.
Health surveillance of employees of triclosan production by an occupational health professional is guaranteed. Workplace health risk assessments are performed regularly.
In the context of medical check-ups over a decade of time medical complaints of production employees, which may be attributed to Irgasan DP 300, were not observed.
In particular did no diseases occur, which required declaration to local accident insurance as potential occupational disease.
Ambient monitoring is part of measures of occupational hygiene surveillance of employees of Triclosan production.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.