Registration Dossier
Registration Dossier
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EC number: 424-590-8 | CAS number: 98298-66-9 CARBONATE DE CHLORO-1-ETHYLE ET ISOPROPYLE
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Test was carried out according to EU test guideline B14 and in compliance with GLP. Data entered as supplied by ECHA following an inquiry for the same substance.
Data source
Reference
- Reference Type:
- other: study summary provided by ECHA
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.13/14 (Mutagenicity - Reverse Mutation Test Using Bacteria)
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Chloro-1-ethyl isopropyl carbonate
- EC Number:
- 424-590-8
- EC Name:
- Chloro-1-ethyl isopropyl carbonate
- Cas Number:
- 98298-66-9
- Molecular formula:
- C6H11ClO3
- IUPAC Name:
- 1-chloroethyl propan-2-yl carbonate
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- S. typhimurium, other: TA 98, TA 100, TA 1535, TA 1537 and TA 1538
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9 Mix
Results and discussion
Test resultsopen allclose all
- Species / strain:
- S. typhimurium, other: TA 98, TA 100, TA 1535, TA 1537 and TA 1538
- Metabolic activation:
- without
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- > 10 000 ug/plate
- Species / strain:
- S. typhimurium, other: TA 98, TA 100, TA 1535, TA 1537 and TA 1538
- Metabolic activation:
- with
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- > 10 000 ug/plate
- Additional information on results:
- Observations: The toxic concentrations for the bacteria are given for the most sensitive strain
- Remarks on result:
- other: other: Main test
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
study summary provided by ECHA, no further detail was given
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
positive without metabolic activation
positive with metabolic activation
The substance was shown to cause cytotoxicity with and without metabolic activation. - Executive summary:
The substance was shown to cause cytotoxicity with and without metabolic activation.
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