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EC number: 217-682-2 | CAS number: 1929-82-4
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
NOEC (wet weight) = 1.38 mg a.i./L; NOEC (egg hatchability, fry survival, and standard length) = 2.87 mg a.i./L; (fathead minnow), OECD 210, Rebstock (2011)
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 1.38 mg/L
Additional information
The long term toxicity of the test material to fish was investigated in an early life-stage toxicity study. The study was conducted under GLP conditions and in accordance with the standardised guideline OECD 210.
Newly fertilised eggs, of fathead minnow, were used to initiate the test, with exposure continuing for 28 days post-hatch. Fish were exposed to nominal concentrations of 0 (dilution water control), 0 (vehicle control), 0.050, 0.10, 0.20, 0.40, 0.80, 1.6 and 3.2 mg a.i./L, under flow-through conditions. The toxicological endpoints of concern were egg hatchability, post-hatch fry survival, and growth. Evidence of any abnormal physical changes in the embryos and/or fry, as well as abnormal behaviours, were also noted.
Hatching success in the control and vehicle control was 95 and 94 %, respectively, and ranged from 89 to 95 % in the test material treatments. Post-hatch survival of fry in the control and vehicle control was 93 and 84 %, respectively, and ranged from 80 to 94 % in the test material treatments. Mean standard length was 17.3 and 18.0 mm in the control and vehicle control, respectively, and ranged from 17.0 to 18.8 mm in the test substance treatments. Mean blotted wet weight was 0.1024 and 0.1146 g in the control and vehicle control, respectively, and ranged from 0.0833 to 0.1277 g in the test material treatments. Water quality parameters were within acceptable limits throughout the exposure.
Based on mean measured concentrations of test material, the NOEC for fathead minnow egg hatchability, fry survival, and standard length was 2.87 mg a.i./L. The NOEC, LOEC, and MATC values for blotted wet weight, the most sensitive endpoint, were 1.38, 2.87, and 1.99 mg a.i./L, respectively.
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