Registration Dossier
Registration Dossier
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EC number: 214-353-5 | CAS number: 1122-58-3
Toxicity to reproduction
Administrative data
- Endpoint:
- toxicity to reproduction
- Remarks:
- other: fertility SAR
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Validated QSAR model for fertility effects from teratology and multigenerational reproductive toxicity studies
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- Computer modeling using MultiCASE SAR to predict whether a substance has adverse effects on reproduction
- GLP compliance:
- no
Test material
- Reference substance name:
- N,N-dimethylpyridin-4-amine
- EC Number:
- 214-353-5
- EC Name:
- N,N-dimethylpyridin-4-amine
- Cas Number:
- 1122-58-3
- Molecular formula:
- C7H10N2
- IUPAC Name:
- N,N-dimethylpyridin-4-amine
Constituent 1
Results and discussion
Results: P0 (first parental generation)
Reproductive function / performance (P0)
- Reproductive function: oestrous cycle:
- no effects observed
- Reproductive function: sperm measures:
- no effects observed
- Reproductive performance:
- no effects observed
Effect levels (P0)
open allclose all
- Dose descriptor:
- other: female fertility effects
- Sex:
- female
- Basis for effect level:
- other: The substance does not contain a structural alert for adverse reproductive effects (female); "inactive"
- Remarks on result:
- not measured/tested
- Remarks:
- Effect level not specified (migrated information)
- Dose descriptor:
- other: male reproductive effects
- Sex:
- male
- Basis for effect level:
- other: The substance does not contain a structural alert for adverse reproductive effects (male); "inactive"
- Remarks on result:
- not measured/tested
- Remarks:
- Effect level not specified (migrated information)
- Dose descriptor:
- other: effects in sperm
- Sex:
- male
- Basis for effect level:
- other: The substance does not contain a structural alert for reproductive toxicity (male sperm effects); "inactive"
- Remarks on result:
- not measured/tested
- Remarks:
- Effect level not specified (migrated information)
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Any other information on results incl. tables
In three validated SAR models, no structural alerts for reproductive toxicity were found for DMAP. The substance was predicted to be "inactive" for reproductive toxicity. This covers female fertility and estrus effects, and male fertility and sperm effects.
Applicant's summary and conclusion
- Conclusions:
- In three validated SAR models, DMAP was predicted to be "inactive" or "negative" for reproductive toxicity, including female and male fertility and estrus and sperm effects.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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