Registration Dossier
Registration Dossier
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EC number: 214-353-5 | CAS number: 1122-58-3
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This is a summary of a study reviewed by an authoritative body, the U.S. Environmental Protection Agency (EPA), which accepted the data as scientifically valid. No detailed data are provided.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1300 (Acute inhalation toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 4-aminopyridine
- IUPAC Name:
- 4-aminopyridine
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- animals are between 8 and 12 weeks of age.
Temperature 22 ± 3 oC, 30-70% humidity.
Light/dark cycle: 12/12 hours
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 4 h
- Concentrations:
- no data
- No. of animals per sex per dose:
- 5
- Details on study design:
- MMAD particle size is 1-4 µm.
Animals were exposed for 4 hours. They were observed daily for 14 days for clinical signs, and at sacrifice they underwent a gross necropsy.
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 0.53 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
Any other information on results incl. tables
The LC50 of 0.5 mg/L corresponds to GHS Category 3, according to Regulation EC No. 1272/2008, as the LC50 values is between 0.25 and 1 mg/L. It was previously reported to be in Category 2 according to the U.S. OSHA Hazard Communication Standard (0.25 ≤ LC50 ≤ 1.0 mg/L), which is no longer in effect.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- The LC50 of 4-aminopyridine is reported to be 0.53 mg/L after 4 hours exposure, after testing of particles 1-4 µm in diameter. This corresponds to Category 3, according to Regulation EC No. 1272/2008, as the LC50 values is between 0.25 and 1 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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