Registration Dossier
Registration Dossier
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EC number: 940-679-9 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Additional information:
Benzenesulphonic acid, dimethyl-,mono C14-16-alkyl derivative (H250 sulphonic acid) is a UVCB. Based on structural and functional similarities, data on Benzenesulphonic acid, 4-C10-13-sec-alkyl derivatives (LABS; CAS no: 85536-14-7) being registered under REACH, LABS Na (CAS no: 68411-30-3) being registered under REACH and LAB (CAS no: 67774-74-7) being registered under REACH are suitable as supporting study in case where specific data on the substance is lacking.
No study on skin sensitisation is available with the substance. Benzenesulphonic acid, 4-C10-13-sec-alkyl derivatives (LABS, CAS No: 85536 -14-7) was used to cover this endpoint as structural analogue substance.
A group of 10 male and 10 female guinea pigs were used to determine the potential of the test substance to be sensitising to skin according to test protocol from Magnusson and Kligman (1969) study. The animals were first given an intradermal induction of 0.05% of test substance in corn oil. One week later, they were given a dermal induction of 5% test substance in corn oil. A group of 5 male and 5 female guinea pigs were used as controls. These animals were treated in a similar fashion with vehicle only. Two weeks after the dermal induction, a challenge was performed via dermal exposure to 2.5% test substance in corn oil. The control group was exposed as well. The animals were exposed for 24 hrs. Skin irritation readings were made at 24 and 48 hrs after the end of exposure. No positive responses were seen in either the test or control group. The test substance is not sensitising to skin.
Migrated from Short description of key information:
No study on skin sensitisation is available with the substance. Data from Benzenesulphonic acid, 4-C10-13-sec-alkyl derivatives (LABS, CAS No: 85536-14-7) was used to assess the skin sensitisation potential of the substance. The guinea-pig maximization test was performed to substance and it showed that the substance is considered not sensitising to skin. Based on data from analogue substance, H250 sulphonic acid is considered not sensitising to skin.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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