Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 940-679-9 | CAS number: -
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No data on chronic toxicity to aquatic invertebrates is available for H250 sulphonic acid. Data from LABS Na (CAS no: 68411-30-3) as structural analogue was used to understand the chronic toxicity profile of substance to daphnia. The 21-d NOEC was 1.18 mg/L.
Key value for chemical safety assessment
Additional information
Benzenesulphonic acid, dimethyl-,mono C14-16-alkyl derivative (H250 sulphonic acid) is a UVCB. Based on structural and functional similarities, data on Benzenesulphonic acid, 4-C10-13-sec-alkyl derivatives (LABS; CAS no: 85536-14-7) being registered under REACH, LABS Na (CAS no: 68411-30-3) being registered under REACH and LAB (CAS no: 67774-74-7) being registered under REACH are suitable as supporting study in case where specific data on the substance is lacking.
There is no chronic aquatic invertebra study available with H250 sulphonic acid. The study from LABS Na (CAS no: 68411-30-3) as structural analogue was used to cover this endpoint.
The chronic toxicity to aquatic invertebra of 11.8 LABS Na was determined in a 21 day survival and reproduction test following OECD 211 guideline study. Four replicates per concentration, 5 organisms per replicate, were tested in a flow-through system (a modified Mount and Brungs proportional diluter). Mean measured concentrations were 0.32, 0.59, 1.18, 2.52, and 4.85 mg/L C11.8LAS (active ingredient), and control. Survival was monitored at 24 hr, 96 hr, 7 days and daily thereafter. Reproduction was monitored beginning with the production of the first brood on day 7 or 8, and daily thereafter. LC50s and EC50s were calculated by probit analysis. Results are based on the mean measured concentration of the active ingredient. The 21-day NOEC was 1.18 mg/L, based on both survival and reproduction. The 21-day LC50 was 1.67 mg/L (95% CL 1.28 -2.18 mg/L). The 21-day EC50s, based on total young production, average brood size, and % days reproduction occurred, were 1.50, 2.30, and 2.31 mg/L, respectively.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
