Ferric ammonium citrate

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

1990

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: The study was conducted according to a protocol equivalent to current OECD guideline, but not in compliance with GLP.

Data source

Reference

Reference Type:

publication

Title:

A simple method for screening assessment of acute toxicity of chemicals

Author:

Yamanaka

Year:

1990

Bibliographic source:

Arch. Toxicol. 64: 262-268

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: Toxicity Guidelines of Japan (Ministry of Health and Welfare in Japan 1984)

GLP compliance:

not specified

Test type:

fixed dose procedure

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Ammonium sulphate

EC Number:

231-984-1

EC Name:

Ammonium sulphate

Cas Number:

7783-20-2

Molecular formula:

N2H8SO4

IUPAC Name:

diammonium sulfate

Constituent 2

Reference substance name:

Ammonium sulfate

IUPAC Name:

Ammonium sulfate

Details on test material:

- Name of test material (as cited in study report): Ammonium sulfate CAS 7783-20-2
- Molecular formula (if other than submission substance):
- Molecular weight (if other than submission substance):
- Smiles notation (if other than submission substance):
- InChl (if other than submission substance):
- Structural formula attached as image file (if other than submission substance): see Fig.
- Substance type:
- Physical state:
- Analytical purity:
- Impurities (identity and concentrations):
- Composition of test material, percentage of components:
- Isomers composition:
- Purity test date:
- Lot/batch No.:
- Expiration date of the lot/batch:
- Radiochemical purity (if radiolabelling):
- Specific activity (if radiolabelling):
- Locations of the label (if radiolabelling):
- Expiration date of radiochemical substance (if radiolabelling):
- Stability under test conditions:
- Storage condition of test material:
- Other:

Test animals

Species:

other: rats and mice

Strain:

other: rats: Wistar, mice: ddy

Sex:

male/female

Administration / exposure

Type of coverage:

open

Vehicle:

not specified

Duration of exposure:

Single application

Doses:

2000, 200, 20 mg/kg

No. of animals per sex per dose:

3 rats and 3 mice of both sexes

Control animals:

no

Results and discussion

Effect levels

Effect levels 1

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Remarks on result:

other: rat

Effect levels 2

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Remarks on result:

other: mouse

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The LD50 values of >2000 mg/kg bw in rat and >2000 mg/kg bw in mice are reported in a published study conducted according to a protocol similar to current guideline, but not in compliance with GLP.