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EC number: 211-334-3
CAS number: 638-38-0
In a reverse gene mutation test in bacteria
(Ames test), strains TA 1535, TA 1537, TA 97, TA 98 and TA 100 of S.
typhimurium were exposed to Manganese (II) sulphate monohydrate in
distilled water in at least five different concentrations up to 10
mg/plate in the presence and absence of mammalian metabolic activation
(hamster and rat S9, preincubation). The positive controls induced the
appropriate responses in the corresponding strains.
There was no evidence of induced mutant
colonies over background.
The study is classified as acceptable due to
its good execution similar to OECD 471 with only minor restrictions and
satisfies the requirements for Test Guideline OECD 471 for in vitro
bacterial gene mutation data.
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