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EC number: 211-334-3
CAS number: 638-38-0
Spirostomum ambiguum: EC50 (24h) 287.5 ± 138.5 mg/L, EC50 (48h) 337.7 ± 205.4 mg/L, LC50 (24h) 458.6 ± 48.0 mg/L and LC50 (48h) 452.4 ± 60.4 mg/L, based on occurrence of different deformations resp. lethal response , corrected for manganese (II) acetate.Tetrahymena pyriformis: EC50 (1h) 83.5 mg/L and the IC50 (9h) 650.6 mg/L, based on metabolic activity resp. growth inhibition, corrected for manganese (II) acetate
There are two studies available on other
aquatic organisms, conducted with the manganese cation. Although no
mandatory endpoint under REACH, these studies on protozoae can be used
to support the conclusion drawn in IUCLID chapter 6.1.5 "Toxicity on
aquatic plants and cyanobacteria".
Within the two available studies, the
information gained from Spirostomum ambiguum are considered to be the
more reliable ones because the test duration was up to 48 h instead of 9
h, and results in the more sensitive response.
Since also both studies were assessed to be
reliable with restrictions, the results can considered to be
trustworthy. Since Spirostomum ambiguum serves as an additional species
to assess the possible hazard of the test item to the environment, the
same criteria for classification or non-classification should apply as
for algae and other aquatic plants.
Taking into account the retrieved results,
i.e. EC50 (24h) 287.5 ± 138.5 mg/L, EC50 (48h) 337.7 ± 205.4 mg/L, LC50
(24h) 458.6 ± 48.0 mg/L and LC50 (48h) 452.4 ± 60.4 mg/L, based on
occurrence of different deformations resp. lethal response , corrected
for manganese (II) acetate from the free cation, it can be assumed that
the EC50 and LC50 values after 72 h are unlikely to be significantly
lower. As Manganese (II) acetate as an inorganic salt has no potential
for bioaccumulation and is no subject to biodegradation, Manganese (II)
acetate does not need to be classified as hazardous to the aquatic
This result is in congruence with the
results obtained from the toxicity study in algae.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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