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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Data derived from IUCLID 4 dataset of Potassium acetate, which can be freely downloaded from the EINECS search page (http://esis.jrc.ec.europa.eu/). Only basic data given, no further information can be retrieved.

Data source

Reference
Reference Type:
secondary source
Title:
Unnamed
Year:
2000
Report date:
1981

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Deviations:
not specified
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Potassium acetate
EC Number:
204-822-2
EC Name:
Potassium acetate
Cas Number:
127-08-2
Molecular formula:
C2H4O2.K
IUPAC Name:
potassium acetate
Test material form:
other: commercial formulation
Details on test material:
- Name of test material (as cited in study report): potassium acetate.
- Substance type: commercial formulation
- Physical state: liquid

Test animals

Species:
rabbit
Strain:
not specified
Details on test animals or test system and environmental conditions:
no data

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
no data
Duration of treatment / exposure:
no data
Observation period:
no data
Number of animals:
no data
Details on study design:
no data

Results and discussion

In vivo

Results
Remarks on result:
other: No details on "Irritation parameter", "Time point" and "Score"; however, the available information is nevertheless considered to be sufficient to cover this endpoint.
Irritant / corrosive response data:
not irritating

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: not specified
Conclusions:
It was concluded that Potassium acetate is not irritating. Although the reliability of the study cannot be assessed due to lacking data, the results are in congruence with a scientifically expected outcome. Potassium acetate does not need to be classified as skin irritant, and since it serves as a read-across substance for Manganese (II) acetate, the latter does not need to be classified, too.
Executive summary:

In a OECD 404 guideline study, a commercial formulation of potassium acetate was tested in rabbits for its skin irritating potency. Potassium acetate was not irritating to the rabbit skin, and since it serves as a read-across substance for Manganese (II) acetate, the latter does not need to be classified as skin irritant, too.