Hexahydro-4,7-methano-1H-indenyl acrylate

Acute Toxicity: other routes

Administrative data

Endpoint:

acute toxicity: other routes

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

29 Jun - 13 Sep 1966

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Meets generally accepted scientific standards, well documented and acceptable for assessment.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1966

Report date:

1966

Materials and methods

Principles of method if other than guideline:

The study was conducted following a protocol based on BASF-internal standards.

GLP compliance:

no

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Hexahydro-4,7-methano-1H-indenyl acrylate

EC Number:

235-697-2

EC Name:

Hexahydro-4,7-methano-1H-indenyl acrylate

Cas Number:

12542-30-2

Molecular formula:

C13 H16 O2

IUPAC Name:

2-Propenoic acid hexahydro-4,7-methano-1H-indenyl ester

Details on test material:

Name of the test substance used in the study report: Dihydrodicyclopentadienylacrylat roh
Analytical purity: no data given

Test animals

Species:

mouse

Strain:

not specified

Sex:

male/female

Details on test animals or test system and environmental conditions:

Mice described as "Kisslegg"-Mice (not clear if supplier, strain etc. is meant)

Administration / exposure

Route of administration:

intraperitoneal

Vehicle:

water

Details on exposure:

The test substance was administered in concentrations of 2, 8, 20 or 30% (aqueous emulsion with traganth)

Doses:

200, 400, 800, 1000, 1250, 1600, 3200 µl/kg bw
(corresponding to 216, 432, 864, 1080, 1350, 1728, 3456 mg/kg bw; density of substance 1.08 g/cm3)

No. of animals per sex per dose:

5

Control animals:

no

Details on study design:

- Duration of observation period following administration: 7 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

ca. 1 404 mg/kg bw

Based on:

test mat.

Mortality:

Two lowest dose groups: no mortalities.
1080 mg/kg bw: 2/10 after 7 days
1350 mg/kg bw: 4/10 after 7 days
1728 mg/kg bw: 7/10 after 7 days
3456 mg/kg bw: all animals died
LD50: 1404 mg/kg bw (1.3 ml/kg bw)

Clinical signs:

3456 mg/kg: 2 h after injection abdominal position. Narcosis-like condition. Crampy convulsions.
1728, 1350, 1080 mg/kg bw: day of injection similar to highest dose group without narcosis-like condition. Hindlimbs sprawled out. Irregular respiration. Moderate tremor. Eyes stuck shut. Piloerection. Clinical signs were reversible in the animals that survived.

Gross pathology:

After necropsy, nothing abnormal was detected.

Any other information on results incl. tables

Table 1: Mortality rates after application (i.p.) of test substance to male and female mice.

Dose (µl/kg bw)	Dose (mg/kg bw)	Conc. (%)	Number of animals	Number of dead animal within
				1 h	24 h	48 h	7 d	14 d
3200	3456	30	10	0/10	10/10	10/10	10/10	-
1600	1728	20	10	0/10	1/10	3/10	7/10	-
1250	1350	20	10	0/10	1/10	3/10	4/10	-
1000	1080	20	10	0/10	0/10	1/10	2/10	-
800	864	8	10	0/10	0/10	0/10	0/10	-
400	432	8	10	0/10	0/10	0/10	0/10	-
200	216	2	10	0/10	0/10	0/10	0/10	-