Registration Dossier
Registration Dossier
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EC number: 235-697-2 | CAS number: 12542-30-2
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Secondary literature, comparable to guideline study without detailed information. Documentation peer-reviewed.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List VIII
- Author:
- Carpenter, C. P., et al.
- Year:
- 1 974
- Bibliographic source:
- Toxi. appl. Pharmacol. 28, 313-319
- Reference Type:
- publication
- Title:
- Range-finding toxicity data: list VI.
- Author:
- Smyth et al.
- Year:
- 1 962
- Bibliographic source:
- Amer. Ind. Hyg. Ass. J. 23, 95-107.
- Reference Type:
- publication
- Title:
- Use of moving averages and interpolation to estimate median-effective dose.
- Author:
- Thompson WR
- Year:
- 1 947
- Bibliographic source:
- Bact. Reviews, 11: 115.
Materials and methods
- Principles of method if other than guideline:
- Method is described in Smyth (1962).
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- Hexahydro-4,7-methano-1H-indenyl acrylate
- EC Number:
- 235-697-2
- EC Name:
- Hexahydro-4,7-methano-1H-indenyl acrylate
- Cas Number:
- 12542-30-2
- Molecular formula:
- C13 H16 O2
- IUPAC Name:
- 2-Propenoic acid hexahydro-4,7-methano-1H-indenyl ester
- Details on test material:
- Name of test substance: Acrylic acid, dicyclopentadienyl ester
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.5 - 3.5 kg
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- REMOVAL OF TEST SUBSTANCE
- Time after start of exposure: 24 h - Duration of exposure:
- 24 h
- Doses:
- no data
- No. of animals per sex per dose:
- 4
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Statistics:
- LD50 was calculated according to Thompson (1947).
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 4 881 mg/kg bw
- Mortality:
- A LD50 was calculated to be 4.52 (2.08 - 9.8) ml/kg bw , corresponding to 4881 (2246 - 10584) mg/kg bw.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information
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