Hexahydro-4,7-methano-1H-indenyl acrylate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Comparable to guideline study, well documented and acceptable for assessment.

Data source

Reference

Reference 1

Reference Type:

study report

Title:

Unnamed

Year:

1980

Report date:

1980

Reference 2

Reference Type:

study report

Title:

Unnamed

Year:

2003

Report date:

2003

Reference 3

Reference Type:

other company data

Title:

Unnamed

Year:

2002

Report date:

2002

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Version / remarks:

(adopted 1981)

Deviations:

yes

Remarks:

Only two doses tested (as compared to three or more as recommended in the guideline)

Principles of method if other than guideline:

according to BASF-internal standard

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Hexahydro-4,7-methano-1H-indenyl acrylate

EC Number:

235-697-2

EC Name:

Hexahydro-4,7-methano-1H-indenyl acrylate

Cas Number:

12542-30-2

Molecular formula:

C13 H16 O2

IUPAC Name:

2-Propenoic acid hexahydro-4,7-methano-1H-indenyl ester

Details on test material:

- Name of the test substance used in the study report: Dicyclopentadienylacrylat (abbreviation: DCPA)
- Analytical purity: 99%

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

- Mean body weight of male animals: 205 g; mean body weight of female animals: 180 g
- Diet (ad libitum): HERITAN MRH-Haltung, complete diet for mice, rats, and hamsters, Heinrich Eggersmann, Rinteln.
- Water (ad libitum): tap water

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

CMC (carboxymethyl cellulose)

Details on oral exposure:

0.5% CMC solution (concentration 50% w/v)

Doses:

6810 and 10000 mg/kg bw

No. of animals per sex per dose:

5

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight

Statistics:

No statistics performed.

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

ca. 10 000 mg/kg bw

Based on:

test mat.

Mortality:

6810 mg/kg bw: 1/5 females after 14 days
10000 mg/kg bw: 1/5 females and 3/5 males after 14 days

Clinical signs:

other: In the 1st test week: Loss of weight, protracted onset of death and poor general state. Nonspecific signs as apathy, aggressiveness, staggering, tremor, spastic gait, diarrhoea.

Gross pathology:

Animals that died: Heart: acute dilatation and acute passive hyperemia; stomach: dilatation; intestines: atonic.
Sacrificed animals: Organs: no abnormalities detected

Any other information on results incl. tables

Mortality:

 

Dose [mg/kg bw]	Conc. [%]	No. of animals/sex	Dead animals / treated animals after
			1 h	24 h	48 h	7 d	14 d
10000	50.0	5 m	0/5	0/5	0/5	3/5	3/5
		5 f	0/5	0/5	0/5	1/5	1/5
6810	50.0	5 m	0/5	0/5	0/5	0/5	0/5
		5 f	0/5	0/5	0/5	1/5	1/5

m: male

f: female