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Diss Factsheets

Toxicological information

Acute Toxicity: dermal

Currently viewing:

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from publication

Data source

Referenceopen allclose all

Reference Type:
other: authoritative database
Title:
Acute Dermal toxicity - Test chemical
Author:
U.S. National Library of Medicine
Year:
2018
Bibliographic source:
ChemIDplus
Reference Type:
publication
Title:
Acute dermal toxicity data for test chemical
Author:
D.L.J Opdyke
Year:
1973
Bibliographic source:
Food and Cosmetics Toxicology June 1973
Reference Type:
other: authoritative database
Title:
Acute dermal toxicity study of test chemical in rabbits
Author:
IFA GESTIS
Year:
2018
Bibliographic source:
Gestis Substance Database ,2018
Reference Type:
other: Authoritative database
Title:
Acute dermal toxicity study of test chemical
Author:
RTECS
Year:
2018
Bibliographic source:
RTECS (registry of toxic effect of chemical substance data base), 2018

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: As mentioned below
Principles of method if other than guideline:
To determine the acute dermal toxicity of test chemical in rabbits.
GLP compliance:
not specified
Test type:
other: not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Methyl o-aminobenzoate
Cas Number:
134-20-3
Molecular formula:
C8H9NO2
IUPAC Name:
Methyl o-aminobenzoate
Test material form:
liquid
Details on test material:
IUPAC name: 2-Aminobenzoic acid, methyl ester
Mol. formula: C8H9NO2
Molecular Weight: 151.1641 gm/mol
Smiles: c1(c(cccc1)N)C(OC)=O
InChI: 1S/C8H9NO2/c1-11-8(10)6-4-2-3-5-7(6)9/h2-5H,9H2,1H3

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Details on dermal exposure:
not specified
Duration of exposure:
not specified
Doses:
5000 mg/kg bw
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Remarks on result:
not determinable due to absence of adverse toxic effects
Mortality:
not specified
Clinical signs:
other: not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Conclusions:
Acute dermal toxicity study of the test chemical was performed on rabbits. An LD50 of >5000 mg/kg bw was observed indicating that the test chemical is not classified.
Executive summary:

Acute dermal toxicity test was performed to determine the toxic nature of test chemical on rabbits. The test chemical was applied on skin of rabbits. An LD50 of >5000 mg/kg bw was observed indicating that the test chemical is not toxic in nature and can be categorized as 'Not classified' according to CLP regulation.