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EC number: 213-651-2
CAS number: 998-40-3
EYE IRRITATION:Inconclusive (Similar to OECD 405), Auletta (1985)
However, the study does not need to be conduceted beacuease the subtance is sponeously flammable in iar at room temeprature.
In the key study, Auletta (1985), the eye irritation potential of the
test material to the New Zealand White rabbit was investigated in a
study conducted using methodology similar to the standardised guideline
OECD 405. Due to the limitations of the methodology of the study, a
reliability score of 4 was assigned in accordance with the criteria for
assessing data quality as described in Klimisch et al. (1997).
The undiluted test material was administered at a dose of 0.1 mL to the
conjunctival sac of the eye in the first of six animals. Upon
administration of the test material, any material on the eyelids or hair
around the eyes ignited. The fire was extinguished with pressure from
paper towels. Based on this, the test material was considered to be too
reactive and no further animals were dosed. The single female rabbit
administered with the test material was observed for 72 hours for signs
Mild, transient ocular irritation consisting primarily of conjunctival
chemosis and discharge with the most severe effects noted at 24 hours
was observed. No corneal changes were seen.
Periorbital erythema and chemosis apparently resulting from the ignition
of the periorbital hair at the time of dosing were noted. This was still
evident after 72 hours.
The irritancy potential of the test material cannot be concluded from
this study due to the use of a single animal. The study was terminated
after administration to the first animal due to the pyrophoric
properties of the substance.
The available information is not sufficient to draw conclusions on the
skin and eye irritation/corrosion potential of the substance in
accordance with Annex I of the regulation EC 1272/2008 (CLP) but no
further study is required because the substance is spontaeously
flammable in air at room temperature.
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