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EC number: 201-302-7
CAS number: 80-70-6
- The toxicity of TMG is based on its
strong corrosivity (pH > 12.5).
- log Pow value between -1 and 4,
favouring absorption by passive diffusion; favorable for adsorption with
a MW just below 200 g/mol.
- Without substance-specific
absorption data, default absorption values are used for DNEL derivation
(see ECHA GD R.8.4.2.): 100% for inhalation, 50% for oral absorption and
a default factor of 1 in the case of oral-to-dermal extrapolation.
No data are available that describe
the toxicokinetics of TMG, CAS 80-70-6, therefore relevant substance
properties and data from toxicity studies indicating systemic
bioavailability were taken together to assess the general toxicokinetics
of the substance.
CAS 80-70-6 is a light yellow, liquid with a characteristic amine-like
odour. It has a MW of 115.1768 g/mol, a vapour pressure of 2.9 hPa @20
°C and thus the saturated vapour concentration is calculated to be 13.8
mg/L. It is miscible with water at any ratio and has a log Pow of -0.49
@20 °C. With a pH > 12.5 is is a strong alkaline substance (additional
information in IUCLID section 4.7).
Data from acute and repeated dose
TMG is harmful after single ingestion
(LD50 (oral, rat) = 835 mg/kg; 1982).The major pathological findings
noted at necropsy were associated with the stomach, gastrointestinal
tract and lungs. Data on the irritancy of the test article and the
extreme alkalinity of the test article formulations suggest a severe
irritant or corrosive effect on the intestinal linings and tissues with
the delayed deaths being possibly due to resultant peritonitis.
Furthermore, an oral OECD422 study in rat is available with doses of 0,
10, 30 and 100 mg/kg bw/d administered per gavage (2018). The observed
adverse findings were erosions in the glandular stomach of some females
in the mid and high dose group and considered to be local effects
resulting from the basic corrosive properties of TMG. Therefore, the
systemic NOAEL in this study is 100 mg/kg bw/d and the local NOAEL is 10
mg/kg bw/d.As TMG is corrosive to the skin (study similar to OECD TG
404; 1982), there are no acute or repeated dose toxicity studies via the
inhalatory or the dermal route available. Additionally, TMG is not
expected to be skin sensitizing (QSAR, 2017) and was not mutagenic in
bacteria and mammalian cell culture (Ames: 2015; HPRT: 2018 and in vitro
In conclusion, the results of the
acute oral and the oral repeated dose toxicity studies indicate that the
toxicity of TMG is based on its strong corrosivity.
Absorption figures used for the
TMG has a log Pow value between -1 and
4, which favors absorption by passive diffusion. Furthermore, the
molecular weight just below 200 makes the test substance also favorable
for adsorption. Overall, this suggests that TMG may be readily absorbed
by the gastrointestinal and respiratory tract. Since it is possible that
TMG will be absorbed and in the absence of substance-specific absorption
data, the default absorption values from the ECHA GD R.8 (Chapter 8,
R.8.4.2) are used for DNEL derivation, namely: 100% for inhalation and
50% for oral absorption. For dermal absorption, a default factor of 1 in
the case of oral-to-dermal extrapolation is included.
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