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Environmental fate & pathways

Henry's Law constant

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Description of key information

From the water surface, 1,1,3,3 -Tetramethylguanidine will not evaporate into the atmosphere.

Key value for chemical safety assessment

Henry's law constant (H) (in Pa m³/mol):
at the temperature of:
25 °C

Additional information


In Article 13 of Regulation (EC) No 1907/2006, it is laid down that information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI (of the same Regulation) are met. According to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used if (1) the scientific validity of the (Q)SAR model has been established, (2) the substance falls within the applicability domain of the (Q)SAR model, (3) the results are adequate for the purpose of classification and labeling and/or risk assessment and (4) adequate and reliable documentation of the applied method is provided.


For the assessment of the 1 ,1,3,3 -Tetramethylguanidine (CAS 80 -70 -6) (Q)SAR results were used for the estimation of the Henry’s Law constant. The criteria listed in Annex XI of Regulation (EC) No 1907/2006 are considered to be adequately fulfilled and therefore the endpoint(s) sufficiently covered and suitable for risk assessment.


Therefore, further experimental studies on the Henry’s Law Constant are not provided.



The bond estimation method gives a value of 5.51E-05 Pa*m³/mol (HENRYWIN Program, v3.20; EPI Suite v4.10; BASF SE, 2018), which is representative for the uncharged molecule. The substance is not within the applicability domain of the model, as the mamiumu number of fragments was exceeded. The substance is expected to be ionized at environmental conditions (pKa = 12.76, SPARC v4.6); therefore, the estimate may overestimate the evaporation potential of the substance. It can be concluded that the substance will not evaporate from the water surface into the atmosphere.