Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 201-302-7 | CAS number: 80-70-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
1,1,3,3-Tetramethylguanidine (CAS 80-70-6) is not readily biodegradable (according to OECD criteria), therefore the substance is assessed to be potentially P or vP. The substance is not expected to significantly bioaccumulate in organisms (based on measured log Kow ≤ 3 and estimated BCF < 2000) and is, therefore, not B or vB. According the experimental toxicity data on algae, the substance is assessed to be not T (NOEC = 100 mg/L, Lonza Ltd, 2017, limit test). According to the available acute toxicity data of the substance to aquatic invertebrates and algae, no effects were observed in the highest test concentration (100 mg/L, limit tests, analytically verified, Lonza Ltd: daphnia: 2015, rep. no.: 698 -202 -0757; algae: 2017, rep. no.: 698 -201 -0756). Therefore, the lowest available acute value is >> 0.1 mg/L and the substance holds no official classification.
Based on the available information, 1,1,3,3-Tetramethylguanidine (CAS 80-70-6) should not be considered as a PBT/vPvB substance.
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