Registration Dossier
Registration Dossier
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EC number: 201-302-7 | CAS number: 80-70-6
Endpoint summary
Administrative data
Description of key information
With high probability 1,1,3,3-Tetramethylguanidine (CAS 80-70-6) is considered to be acutely not harmful to aquatic organisms
Additional information
Short-term toxicity to fish:
With high probability acutely not harmful to fish.
The assessment of the acute toxicity of 1,1,3,3 -Tetramethylguanidine (CAS 80 -70 -6) to fish is based on the data from two valid QSAR estimation models: OECD (Q)SAR Toolbox v4.1 and EPI Suite v4.11 ECOSAR 96-h fathead minnow LC50 v1.11.
OECD (Q)SAR Toolbox v4.1: 1050 mg/L
EPI Suite v4.11 ECOSAR 96-h fathead minnow LC50 v1.11: 957 mg/L
The substance was within the applicability domain of both estimation’s models.
Long-term toxicity to fish: No experimental data available.
Short-term toxicity to aquatic invertebrates:
With high probability the substance is acutely not harmful to aquatic invertebrates.
EC50 (48 h): > 100 mg/L (Daphnia magna, OECD 202, limit test, analytically verified, static)
Long-term toxicity to aquatic invertebrates: No experimental data available.
Growth inhibition to aquatic algae:
With high probability the substance is acutely not harmful to aquatic algae
NOErC (72 h): > 100 mg/L (Pseudokirchneriella subcapitata, OECD 201, static, analytically verified concentrations)
Toxicity to microorganisms:
Depending on local conditions and existing concentrations, disturbances in the biodegradation process of activated sludge are possible.
EC10 (3 h): 17 mg/L; EC50 (3 h) = 350 mg/L (OECD 209; domestic activated sludge)
Therefore, based on the available experimental and calculated data, 1,1,3,3-Tetramethylguanidine (CAS 80-70-6) is considered with high probability to be acutely not harmful to aquatic organisms.
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