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EC number: 231-072-3
CAS number: 7429-90-5
Ichinose et al.(2008) studied allergic inflammation after
intratracheal instillation of Asian sand dust,sand dust, amorphous
silica and Al2O3 in 6-week old male ICR mice.Four instillations
were performed at 2-week intervals.There were ten groups of
animals (n = 16 in each). One of these groups received Al2O3 (particle
size 1~5 µm), a dose of 0.1 mg suspended in saline.The
control group received saline only (0.1 mL). The animals were killed one
day after the last instillation. Eight out of 16 animals in each group
were used for pathologic examination. The lung samples were stained with
haematoxylin and eosin to evaluate the degree of infiltration of
eosinophils or lymphocytes in the airways, and with periodic acid-shiff
to evaluate the degree of proliferation of goblet cells in the bronchial
epithelium. The other 8 mice were used for examination of free cell
counts (total and differential), determination of levels of lactate
dehydrogenase (LDH), cytokines (Interleukins – IL-5, IL-6, IL-12, IL-13,
interferon-IFN-gand tumor necrosis factor- TNF-a) and chemokines in
bronchoalveolar lavage fluids (BALF), and also total IgE in serum using
enzyme-linked immunosorbent assays (ELISA). In the group of mice exposed
to Al2O3, the levels of eosinophil and lymphocyte infiltration in the
submucosa and proliferation of goblet cells in the airways, the level of
LDH, chemokines and interleukins, number of cells in BALF and the level
of IgE in serum were not significantly different from those in the
control mice.The results suggest that intratracheal administration
of Al2O3 does not produce allergic inflammatory effects in the lungs of
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