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EC number: 231-072-3
CAS number: 7429-90-5
The Al BLM developed using gill accumulation
data from S. salar was applied to the chronic Pimephales
promelas data (Oregon State
University Aquatic Toxicology Laboratory 2010;
Figure 188.8.131.52.2.-1). Application
of the model to new data requires development of a critical accumulation
value appropriate for the exposure duration and toxicity endpoint. In
addition, calibration of the model to these data benefited from two
other changes in parameter values. First,
since the chronic endpoints for this species and in these test
conditions were at much higher aluminium concentrations and saturation
of NOM binding sites included in the model was beginning to occur,
resulting in a somewhat reduced predicted effect of NOM compared with
the observed effect. The
binding site density for NOM was increased by two fold to provide
adequate binding sites at these high Al concentrations. In
addition, although the effect of hardness on observed aluminium toxicity
was consistent in acute and chronic exposures, the predicted effect of
hardness could be improved by a small change in the binding strength of
Ca (i.e. the log K for binding at the biotic ligand was increased from
4.2 to 4.8.
After application of the Al BLM, the
variability in the response curve between effects of aluminium on the
biotic ligand was reduced compared with response curve based on total
aluminium (Figure 184.108.40.206.2.-2). Values
for critical accumulation were estimated directly from the predicted
response curve on the biotic ligand to establish the CA10, or the
critical accumulation level that results in a chronic effect of 10% (in
this case a reduction in growth).
Figure 220.127.116.11.2.-3 provides an evaluation of
the ability of the long-term fish BLM to predict EC10 values. In
this case, most of the EC10 values are predicted within 2-fold of the
reported EC10 values, and all of the predicted EC10 values are within
4-fold of the reported values.
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