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EC number: 231-072-3
CAS number: 7429-90-5
An acute oral toxicity study comparable to OECD 401 was performed
with fumed alumina in female and male rats.This study has been
performed at the Hazelton Laboratories, Inc..Fumed alumina was
administered by a single oral gavage to seven groups of five males and
five females per group at dose levels of 1000, 1590, 2510, 3980, 6310,
10000 and 15900 mg/kg bw after an overnight food withdrawal. Parameters
monitored during this study included mortality and clinical signs of
possible intoxication. Clinical observations were performed on all
animals immediately after dosing, at 1, 4 and 24 hours after dosing and
daily for 14 days thereafter. During the 14 days of the observation
period, there was no mortality or clinical signs of intoxication related
to aluminium oxide administration at dose range from 1000 mg/kg to 10000
mg/kg bw. Clinical signs of depression, laboured respiration, and
piloerection (males) were noted immediately and hunched appearance was
noted at 24 hours post-administration of the highest dose 15900 mg/kg.
No significant sex differences were noted among animals in the
sensitivity to the administered compound or during the recovery period.
Animals appeared normal by day 7 (females) and day 8 (males).
Macroscopic examination at the end of the observation period did not
reveal any aluminium-related changes of the internal organs of the
aluminium treated animals compared to the control group.
Under the conditions of this study, the acute oral median lethal dose
(LD50) of the fumed alumina is above 15900 mg/kg bw in both females and
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