Registration Dossier
Registration Dossier
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EC number: 203-309-0 | CAS number: 105-56-6
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- study with acceptable restrictions (inhalation risk test) Ethyl cyanoacetic acid is an ester of cyanoacetic acid. It hydrolyzes rapidly under neutral and alkaline conditions to cyanoacetic acid and ethanol. It ca be assumed that for most endpoints cyanoacetic acid will be the common metabolite that determines the toxicity of both substances.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Smyth et al., Am. Ind. Hyg. Ass. J., (23) 1962
- Principles of method if other than guideline:
- Method:
The study intends to demonstrate the toxicity of an atmosphere saturated with vapors of the volatile components of a test substance. - GLP compliance:
- no
- Test type:
- other: inhalation risk test
Test material
- Reference substance name:
- Reference substance 001
- Details on test material:
- - Name of test material (as cited in study report): Cyanoessigsäure
- Physical state: liquid
Constituent 1
Test animals
- Species:
- rat
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- nose only
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- System of generating vapour: 200 l air are led through a 5 cm layer of the test substance. The temperature is 20 °C. The applied pressure is 766-772 mbar. - Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- ca. 7 h
- Concentrations:
- 0.92 mg/l (199.08 ppm)
- No. of animals per sex per dose:
- 6
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: daily up to 3 days post exposure
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs
Results and discussion
- Mortality:
- No mortality
- Clinical signs:
- other: During 7 h exposure: irritation of mucosa, accelerated and intermittent respiration, lacrimation, eyelid closure
- Gross pathology:
- No treatment related abnormalities were observed.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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