Registration Dossier
Registration Dossier
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EC number: 459-330-2 | CAS number: -
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 1,1,2,2-tetrafluoroethyl-2,2,2-trifluoroethyl ether
- EC Number:
- 609-858-6
- Cas Number:
- 406-78-0
- Molecular formula:
- C4H3F7O
- IUPAC Name:
- 1,1,2,2-tetrafluoroethyl-2,2,2-trifluoroethyl ether
- Test material form:
- liquid
Constituent 1
Study design
- Analytical monitoring:
- yes
- Buffers:
- BUffers were used of pH 4, pH 7 and pH 9
Results and discussion
- Preliminary study:
- In the blank buffer solution a small peak at the test substance position was detected. The contribution of this peak to the samples taken at t=120 hours was less than 0.07% and was therefore considered negligible.
At pH 4, pH 7 and pH 9, a decrease in concentration> 10% was observed after 5 days. This was probably due to the volatility of the test substance, i.e. partial evaporation into a very small volume of headspace. Therefore additional samples were taken after 14 days of incubation. The decrease in concentration between 5 and 14 days of incubation was < 10%. Therefore it was concluded that the half-life time at 25'C is > 1 year. - Transformation products:
- no
Dissipation DT50 of parent compound
- Key result
- Remarks on result:
- hydrolytically stable based on preliminary test
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Based upon the conditions of the test, the preliminary study demonstrated that the test compound is hydrolytically stable.
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