Registration Dossier
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EC number: 604-608-2 | CAS number: 147853-32-5
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
EL50 (72h) > 1000 mg/L (nominal) (Selenastrum capricornutum, OECD 201), RA
NOELR (72h) >= 1000 mg/L (nominal) (Selenastrum capricornutum, OECD 201), RA
No effects up to the limit of the water solubility of the substance.
Key value for chemical safety assessment
Additional information
Since no studies investigating the toxicity to algae of Fatty acids, C18-unsatd., dimers, di-Me esters, hydrogenated (CAS 147853-32-5) are available, in accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5, a read-across to the structurally similar substances Fatty acids, C18-unsatd., dimers (CAS 61788-89-4) and Fatty acids, C18-unsatd., trimers (CAS 68937-90-6) was conducted. Further justification is given in the overall endpoint summary (IUCLID Chapter 6.1) and within the analogue justification attached in IUCLID Section 13.
The key study conducted with Fatty acids, C18-unsatd., dimers (CAS 61788-89-4) was performed as a limit test according to OECD 201 and GLP. The test organism Selenastrum capricornutum was exposed to the test substance at a loading rate of 1000 mg/L, prepared as water accommodated fractions (WAF) (Kelly, 2002). As the treatment had no significant effect on algal growth, the NOELR was reported to be > 1000 mg/L (EL50 > 1000 mg/L).
A supporting study conducted with Fatty acids, C18-unsatd., trimers (CAS 68937-90-6) was performed according to ISO 10253 and GLP. The marine test organism Skeletonema costatum was exposed to the test substance at loading rates of 100, 180, 320, 560 and 1000 mg/L, prepared as water accommodated fractions (WAF) (Källqvist, 2004). As the treatment had no significant effect on algal growth, the NOELR was reported to be ≥ 1000 mg/L (EL50 > 1000 mg/L).
Based on the above mentioned results and the substance similarities in structure and profile as explained within the overall endpoint summary (IUCLID Chapter 6.1), toxicity of Fatty acids, C18-unsatd., dimers, di-Me esters, hydrogenated (CAS 147853-32-5) to aquatic algae and cyanobacteris is not expected up to the limit of water solubility (< 0.1 mg/L).
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