Registration Dossier
Registration Dossier
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EC number: 604-608-2 | CAS number: 147853-32-5
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
NOEC (28d) >= 850 µg/L (measured) (Brachydanio rerio, ISO/DIS 10229-1), RA
No effects up to the limit of the water solubility of the substance.
Key value for chemical safety assessment
Additional information
Since no studies investigating the long-term toxicity to fish of Fatty acids, C18-unsatd., dimers, di-Me esters, hydrogenated (CAS 147853-32-5) are available, in accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5, a read-across to the structurally similar substance Fatty acids, C18-unsatd., dimers, hydrogenated (CAS 68783-41-5) was conducted. Further justification is given in the overall endpoint summary (IUCLID Chapter 6.1) and within the analogue justification attached in IUCLID Section 13.
The key study conducted with Fatty acids, C18-unsatd., dimers, hydrogenated (CAS 68783-41-5) was performed as a limit test according to ISO/DIS 10229-1 and GLP in a flow-through system, using Brachydanio rerio as test organism (Marshall, 1994). The fish were exposed to nominal test concentrations of 200 and 1000 µg/L for 28 days. Due to the low water solubility of the test substance, a vehicle (DMSO) was used. As the treatment had no significant effect on the weight of the fish, the NOEC was determined to be ≥ 850 µg/L (measured value for highest test concentration), which is above the water solubility limit of the test substance.
Based on the above mentioned results and the substance similarities in structure and profile as explained within the overall endpoint summary (IUCLID Chapter 6.1), long-term toxicity of Fatty acids, C18-unsatd., dimers, di-Me esters, hydrogenated (CAS 147853-32-5) to fish is not expected up to the limit of water solubility (< 0.1 mg/L).
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