Registration Dossier
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EC number: 604-608-2 | CAS number: 147853-32-5
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
LC50 (96h) > 350 mg/L (nominal) (Brachydanio rerio, OECD 203), RA
No effects up to the limit of the water solubility of the substance.
Key value for chemical safety assessment
Additional information
Since no studies investigating the short-term toxicity to fish of Fatty acids, C18-unsatd., dimers, di-Me esters, hydrogenated (CAS 147853-32-5) are available, in accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5, a read-across to the structurally similar substance Fatty acids, C18-unsatd., dimers (CAS 61788-89-4) was conducted. Further justification is given in the overall endpoint summary (IUCLID Chapter 6.1) and within the analogue justification attached in IUCLID Section 13.
The key study conducted with Fatty acids, C18-unsatd., dimers (CAS 61788-89-4) was performed according to OECD Guideline 203 in a static system, using Brachydanio rerio as test organism (Benijts, 2002). No details on preparation of test solutions were provided. The fish were exposed to nominal test concentrations of 0.02, 0.04, 0.07, 0.10, 0.15, 0.25, 0.30 and 0.35 g/L for 96 hours. As no mortality occurred during the study, the LC50 was determined to be > 350 mg/L.
A supporting study conducted with Fatty acids, C18-unsatd., dimers (CAS 61788-89-4) was performed according to the guideline “Bewertung wassergefährdender Stoffe, Bestimmung der akuten Fischtoxizität, Ad-hoc Arbeitsgruppe 1, LTwS, Nr. 10, Sept 1979” which is comparable to DIN 38412 L15 (Bogers, 1988). The test organism Cyprinus carpio was exposed to the test substance in a static system at a nominal concentration of 1000 mg/L.The test concentration of 1000 mg/L was described as a non-homogenous suspension with clear visibility of undissolved test substance, which confirms the high insolubility of the test substance. After 48h one out of ten fish died and an LC50 (48h) > 1000 mg/L was stated. Thus, the LC50 is determined to be greater than the water solubility of Fatty acids, C18-unsatd., dimers (< 0.12 mg/L).
Based on the above mentioned results and the substance similarities in structure and profile as explained within the overall endpoint summary (IUCLID Chapter 6.1), short-term toxicity of Fatty acids, C18-unsatd., dimers, di-Me esters, hydrogenated (CAS 147853-32-5) to fish is not expected up to the limit of water solubility (< 0.1 mg/L).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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