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EC number: 293-917-2
CAS number: 91648-55-4
Table 1: Data availability for toxicokinetics, metabolism and
C11ASO4KCAS not available
Table 2: Metabolites formed from alkyl sulfates with even chain
4-butyrolactone (ring structure)
Glycolic acid sulfate
Major MetaboliteFound in rats, dogs, humans
Minor metaboliteFound in rats, dogs, humans
Minor metaboliteFound in dogs (and humans)
* investigated substances were potassium
salts of C10, C12, C14& C18alkyl
Table 3: Influence of chain length on elimination of alkyl sulfates
Number of animals, sex*
Recovery from urine at 48 h (% of dose)*
Recovery from feces at 48 h (% of dose)*
Recovery from carcass at 48 h (% of dose)*
* mean number of number of animals indicated, all values are mean
values; ** n.a. = not available; 5 mg/kg bw of the35S labeled
compounds was applied i.p. to MRC rats
behaviour of alkyl sulfates was assessed. Alkyl
well absorbed after ingestion. After absorption, these chemicals are
distributed mainly to the liver. Alkyl sulfates are metabolized by
cytochrome P450-dependent w-oxidation
and subsequent beta-oxidation of the aliphatic fatty acids. End products
of the oxidation are a C4sulfate and a C3or C5sulfate.
In addition, for the alkyl sulfates, sulfate is formed as a metabolite.
The metabolites are rapidly excreted in urine. Due
to the low concentrations of the substances in consumer products and the
limited uptake after dermal exposure which is the main route for
consumers, significant exposure of the developing foetus via the
placenta or the neonate via the breast milk is not likely. Therefore a bioaccumulation
of alkyl sulfates is not expected.
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