Registration Dossier
Registration Dossier
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EC number: 293-917-2 | CAS number: 91648-55-4
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to microorganisms
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to national guideline study with acceptable restrictions
- Justification for type of information:
- Refer to the Category Approach Justification document provided in IUCLID6 Section 13.
- Qualifier:
- according to guideline
- Guideline:
- other: cell multiplication inhibition test acc. to Bringmann and Kühn (1977)
- GLP compliance:
- not specified
- Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- Pseudomonas putida
- Test type:
- not specified
- Water media type:
- freshwater
- Total exposure duration:
- 18 h
- Duration:
- 18 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 550 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- growth inhibition
- Endpoint:
- toxicity to microorganisms
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Refer to the Category Approach Justification document provided in IUCLID6 Section 13.
- Reason / purpose for cross-reference:
- read-across source
- GLP compliance:
- not specified
- Test organisms (species):
- Pseudomonas putida
- Water media type:
- freshwater
- Total exposure duration:
- 18 h
- Duration:
- 18 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 550 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- growth inhibition
Referenceopen allclose all
Description of key information
18h NOEC (Pseudomonas putida) = 550 mg/L (growth inhibition, read-across)
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 550 mg/L
Additional information
Since no reliable toxicity tests with microorganisms are available for C16-20AS Na (CAS 91648-55-4), in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 a read-across to another structurally related substance was conducted. Read-across data available for C16-18AS Na (CAS 68955-20-4) were used. Toxicity of alkyls sulfates is dependent on the carbon chain length - homologues of chain length of C13 to C15 are considered as the most toxic from the whole Alkyl Sulfate Category. Toxicity of the chains from C16 and higher will decrease due to lower bioavailability as a consequence of reduced water solubility.
One reliable study with Pseudomonas putida is available for C16-18AS Na (CAS 68955-20-4). The key study (Steber 1988) followed the procedure of cell multiplication inhibition test according to Bringmann and Kühn (1977). The growth inhibition of Pseudomonas putida was recorded after 18 hours of exposure to the test substance. The 18-hour NOEC value was determined to be 550 mg a.i./L (nominal concentration).
Due to structure and property similarities with the tested category member it can be concluded that the above result applies also to C16-20AS Na (CAS 91648-55-4). The 18-hour NOEC value for microorganisms is 550 mg/L. This value was used for the PNEC STP derivation for C1620AS Na (CAS 91648-55-4).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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