Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 944-989-5
CAS number: 2156592-46-8
The evaluation after 24 hours after start of
challenge showed also no signs of erythema or oedema in treated and
1,2,3-Propanetricarboxylic acid, 2-hydroxy-,
tris(C12-13-branched-alkyl) ester was tested in a guinea pig
maximazation test according to OECD Guideline 406.
30 female guinea pigs were used, 10 as
control group and 20 were treated with the test material. The test
material was dissolved in distilled water at a concentration of 100
mg/ml for induction. During the induction phase the test group animals
were first treated with 3 double intradermal injections as follows: 1st:
Freud's complete adjuvant (FCA) in distilled water (1:1), 2nd: test
material in distilled water, 3rd: test material in distilled water and
FCA (1:1). The 10 control animals received the same pairs of injections
but in the 2nd injection only sesame seed oil was used.
After 7 days of intradermal injections the
test material was applied undiluted for a period of 48 hours under an
occlusive dressing.The same treatment was used on the 10 control animals
using only distilled water.
21 days after the beginning of treatment a
challenge phase was performed by applying undiluted test material on the
left side, and distliled water on the right side for 24 hours under
occlusive dressings for both test group and control group animals.
24, 48 and 72 hours after the beginning of
the challenge application the animals were observed for erythema and
oedema. No signs of erythema or oedema were observed in any of the
Therefore the test material
1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tris(C12-13-branched-alkyl)
ester can be considered as non sensitizing.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again