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EC number: 944-989-5
CAS number: -
Table: Irritant/corrosive response
data for each animal at each observation time up to removal of each
animal from the test
Score at time point / Reversibility
Max. score: 4
Max. score: 2
Max. score: 3
Average 24h, 48h, 72h
Average time for reversion
*) Reversibility: c. = completely
reversible; n.c. = not completely reversible; n. = not reversible
An ocular irritation test was carried out on
test material Cosmacol ECI according to OECD Guideline 405.
The test was performed by placing the test
material in a single dose in the conjunctival sac of 6 albino male
rabbits at a dose of 0.1 mL/animal. The animals eyes were examined 1,
24, 48 and 72 hours after the beginning of the test. The ocular areas
obvserved were the cornea, the iris and conjunctivae. The results showed
a slight congestion of the conjunctivae in all 6 rabbits 1 h and in 2 of
6 animals 24, 48, 72 h
after the treatment. After 7 days it
It was concluded that the read-across
substance Cosmacol ECI is to be considered non-irritant to eyes.
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