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Ecotoxicological information

Toxicity to microorganisms

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activated sludge respiration inhibition testing
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
Please see Analogue Approach
Reason / purpose for cross-reference:
read-across source
Key result
3 h
Dose descriptor:
Effect conc.:
> 1 000 mg/L
Nominal / measured:
Conc. based on:
test mat.
Basis for effect:
inhibition of total respiration
respiration rate

Description of key information

In comparison to the inoculum controls the respiration rate of the activated sludge was inhibited between 4.4 % and 20.1 % up to the highest tested concentration of nominal 1000 mg of the source substance Tri (hexyl, octyl, decyl) citrate /L. However, no concentration-effect relationship could be determined. Thus, the respiration rate was not significantly inhibited up to the highest tested concentration. Concentrations exceeding 1000 mg/L nominal were not tested.

From these inhibition rates, the 3-hour EC20 and EC50 could not be quantified. Nevertheless, the 3-hour EC50 was clearly higher than 1000 mg test substance/L under the present test conditions.

It is expected that the result is useful for the target substance 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tris(C12-13-branched-alkyl) ester.

Key value for chemical safety assessment

EC50 for microorganisms:
1 000 mg/L

Additional information