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EC number: 810-298-1
CAS number: 194934-66-2
The study was designed to assess a
mutagenicity potential of dihydrofarnesal using a bacterial reverse
mutation test system. Salmonella typhimurium strains TA100,
TA1535, TA98, TA1537 and Escherichia coli strain WP2uvrA
were tested with and without metabolic activation system, according to
the OECD guideline 471 (21st July, 1997).
A dose-determination test was carried out
in a single plate in order to determine the doses to be tested in the
main test. The main mutagenicity test was performed in twice, three
replicates for each dose, and it was performed using the pre-incubation
method. Sterility conditions, cytotoxicity and precipitation were
Throughout the tests, the test substance
did not induce any increases in the number of revertant colonies is at
least twice as many as that of the negative control for any of the
bacterial strains at any dose levels either with or without metabolic
activation; therefore the test substance was concluded to be
non-mutagenic under the conditions of the test. The test substance
solutions and S9 mix were sterile in the tests.
Cytotoxicity was observed at and above
dose levels of 9.77 μl/plate in TA100, TA1535 and TA1537 strains without
metabolic actiation and at and above dose levels of 39.1 μl/plate in
TA98 strain without metabolic activation and in TA1535 and TA1537
strains with metabolic activation.
Precipitation of the test substance was
observed at 5000 μg/plate with metabolic activation.
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