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EC number: 267-122-6
CAS number: 67801-01-8
Studies on acute toxicity of the test item were not performed. Since both substances are Ba-salts with comparable structur and similar solubility, information on acute toxicity were derived from experimental data of a structural analogue. Four studies were performed to evaluate acute oral and inhalative toxicity of the test substance to the rat (according OECD 401 and 403). The test substance did not induce mortalities, abnormalities or clinical signs when applied oral. Also single administration via the respiratory system did not cause health effects or mortalities. The LD50 for oral toxicity is considered to be > 10.000 mg/kg bw, LC50 is > 5.24 mg/l air.
Acute toxicity of the
test substance was not examined. The test item shares high structural
similarity to an analogue substance, since both are Ba-salts which
differ in one additional ethyl-group only. Both substances are poor
soluble in water and octanol and dissolve most likely in an acidic
environment (e.g. stomach). Therefore, it is acceptable to derive
information on acute toxicity from experimental data of the analogue
To evaluate the acute oral toxicity, single doses (6000 and
10.000 mg/kg bw) of the test article were administrated to groups of 10
male and 10 female rats by oral gavage (Ciba 1973). Following dosing,
the animals were observed for 7d. There were no deaths as a result of
treatment with the test article. Within 2 hours after treatment
rats in both dosage groups showed dyspnoea, exophthalmus, curved
position and ruffled fur. These symptoms became more accentuated as the
dose was increased. The animals had recovered within 3 to 6 days.
Antoher acute oral toxicity study was conducted in 1993 (Hoechst). A
single dose of 2000 mg/kg bw was administrated to groups of 5 rats/sex
by gavage. The animals were observed for 14 days and twice daily checked
for clinical symptoms or mortalities. All animals survided until
scheduled necropsy; gross necropsy did not reveal any findings. Symptoms
like hunched posture or stilted gait resolved within 1 day. In addition,
red stained feces was observed.
To evaluate the acute inhalative toxicity, male and female rats
(5/sex/dose) were exposed for 4h to a dust aerosol (range 4.25 -
6.33 mg/l air, nose only) of the test item (BASF 2010). Following
dosing, the animals were observed for 14d. Examination of clinical signs
and viability were performed daily, weighing on day 1, 7 and 13 after
treatment. There were no deaths as a result of treatment with the test
article. Clinical signs of toxicity or changes in body weight gain were
not observed during the observation period. Gross necropsy was without
Similar results were determined in another inhalation study
(Hoechst 1993). Animals (rats, 5/sex/dose) were exposed to dust (4.13
mg/l air, nose only) for 4h and observed for further 7 days. One male
animal died accidentially during exposure; this death is not considered
as treatment related. All other animals survided until scheduled
necropsy; gross necropsy did not reveal any findings. Symptoms
like irregular respiration, uncoordinated gait or trembling resolved
within post observation period.
Application of the test substance via oral or inhalative route did
not induce any signs of toxicity. None of the animals died due to
treatment, viability and bodyweight gain were unaffected by the test
article. The test item was not tested for acute dermal toxicity. With
regard to the physico-chemical properties of the substance (pH,
structure, solubility), the very limited skin penetration and the
absence of systemic and local effects in acute oral and acute inhalation
studies dermal toxicity is not likely.
Dangerous Substance Directive
The available studies are considered
reliable and suitable for classification purposes under 67/548/EEC. As a
result the substance is not considered to be classified for acute
toxicity under Directive 67/548/EEC, as amended for the 28th time in
Classification, Labelling, and
Packaging Regulation (EC) No. 1272/2008
The available experimental test data
are reliable and suitable for classification purposes under Regulation
1272/2008. As a result the substance is not considered to be classified
for acute toxicity under Regulation (EC) No. 1272/2008, as amended for
the second time in Directive (EC 286/2011).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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