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EC number: 267-122-6
CAS number: 67801-01-8
Rats were given 10.0 mg 131Ba/liter
as sulfate, chloride or carbonate at pH 7.0. Animals were
sacrificed at 2, 5, 10, 20, 30, 60, and 120 minutes and 24
hours after intubation.
was administered, as chloride,131Ba in
blood rose linearly for 10 minutes and then less rapidly
until the highest number of counts was measured at 60
minutes. At 24 hours 131Ba2+ was
still at 90% of peak levels. Five tissues were tested 24
hours after dosing for 131Ba. In decreasing
order of 131Ba concentration they were heart,
eye, skeletal muscle, kidney, and liver 131Ba
in the heart reached 8x that observed in blood 24 hours
after dosing. In the eye, 131Ba increased
linearly for one hour. Isotope concentrations in the eye
eventually reached 2.5x that observed in blood. When 131Ba
was administered as sulfate or carbonate, 131Ba
in blood was respectively 85% or 45% of levels, of 131Ba
from 131Ba given as chloride.
Initial uptake of 131Ba
and deposition in the eye were not different when
administered as chloride or sulfate.
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