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EC number: 267-122-6
CAS number: 67801-01-8
D&C Red No. 9 was administered to mice for two years by incorporation
into the diet at concentrations of 50, 250 and l000 ppm. The high dose
level animals were colored slightly orange. No adverse effect of
treatment was evident based on survival, observations, body weight and
food intake. A decrease in the value of red blood cell parameters in the
high dose females at month 18 indicated a possible compound-related
anemia. The gross and histopathologic evaluation and tumor incidence
analyses did not reveal any compound related effects.
All tumors encountered in the current study were common spontaneously
occurring tumors of. mice or uncommon tumors that affected only
individual mice without regard to treatment group. There was no apparent
treatment-related increase in tumor incidence. There was no apparent
difference between treated and control mice with respect to non-tumorous
lesions encountered in the study. The histopathologic findings indicate
that D&C Red No 9 administered per os at the dose levels employed and
under conditions of this study did not produce morphologically
identifiable evidence of toxigenic effect on CD-1 mice. In addition, the
study yielded no evidence of carcinogenicity.
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