Registration Dossier
Registration Dossier
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EC number: 235-008-5 | CAS number: 12054-48-7
Toxicity to birds
Administrative data
- Endpoint:
- short-term toxicity to birds: dietary toxicity test
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Review-Basic data given but only summary available
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- NICKEL HAZARDS 10 FISH, WILDLIFE, AND INVERTEBRATES-A Synoptic Review
- Author:
- Ronald Eisler
- Year:
- 1 998
- Bibliographic source:
- U.S. Department of the Interior U.S. Geological Survey Patuxent Wildlife Research Center-Biological Science Report USGS/BRD/B SR-1 998-0001
- Reference Type:
- publication
- Title:
- Effects of dietary nickel on mallards
- Author:
- Eastin and O´Shea
- Year:
- 1 981
- Bibliographic source:
- Journal of Toxicology and Environmental Health 7: 883-892 cited in: NICKEL HAZARDS 10 FISH, WILDLIFE, AND INVERTEBRATES-A Synoptic Review
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- GLP compliance:
- no
Test material
- Reference substance name:
- Nickel
- EC Number:
- 231-111-4
- EC Name:
- Nickel
- Cas Number:
- 7440-02-0
- IUPAC Name:
- nickel(2+)
Constituent 1
- Dose method:
- feed
- Analytical monitoring:
- not specified
Test organisms
- Test organisms (species):
- Anas platyrhynchos
- Details on test organisms:
- TEST ORGANISM
- Common name: mallard
- Age at test initiation (mean and range, SD): 20 month old
- Breeding population: yes
Study design
- Limit test:
- no
- Total exposure duration (if not single dose):
- 90 d
- Nominal and measured doses / concentrations:
- 0, 12.5, 50, 200, or 800 mg Ni/kg
Results and discussion
Effect levelsopen allclose all
- Duration (if not single dose):
- 90 d
- Dose descriptor:
- NOEC
- Effect level:
- >= 800 mg/kg diet
- Conc. / dose based on:
- element
- Remarks:
- Nickel
- Basis for effect:
- reproductive parameters
- Remarks:
- egg production and hatchability
- Duration (if not single dose):
- 90 d
- Dose descriptor:
- NOEC
- Effect level:
- >= 800 mg/kg diet
- Conc. / dose based on:
- element
- Remarks:
- Nickel
- Basis for effect:
- mortality
- Duration (if not single dose):
- 90 d
- Dose descriptor:
- NOEC
- Effect level:
- >= 1 263.7 mg/kg diet
- Conc. / dose based on:
- other: Nickeldihydroxid
- Basis for effect:
- reproductive parameters
- Remarks:
- egg production and hatchability
- Remarks on result:
- other: Calculated for Nickeldihydroxid
- Duration (if not single dose):
- 90 d
- Dose descriptor:
- NOEC
- Effect level:
- >= 1 263.7 mg/kg diet
- Conc. / dose based on:
- other: Nickeldihydroxid
- Basis for effect:
- mortality
- Remarks on result:
- other: Calculated for Nickeldihydroxid
Any other information on results incl. tables
No effect on egg production, hatchability, or survival of ducklings; adults had normal blood chemistry and no organ histopathology.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
