Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

Studies were chosen as key when the available study was of relevance and of sufficient quality for classification, labelling and for risk assessment.

In a key skin sensitisation study (Buehler test) conducted according to OECD TG 406 and GLP, showed that (3-chloropropyl)diethoxymethylsilane was not sensitising to the skin of guinea pigs. There were no positive skin responses in 20/20 test group animals following challenge with 100 % test substance. No local or systemic effects were observed in this study (Hüls AG, 1997e).

Migrated from Short description of key information:
Buehler test according to OECD TG 406: not sensitising

Justification for selection of skin sensitisation endpoint:
The key study was selected for assessment.

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification

The available data on skin sensitisation of the registered substance do not meet the criteria for classification according to Regulation 1272/2008 or EU Directive 67/548/EEC, and are therefore conclusive but not sufficient for classification.